I feel like I am at a point in my transition where I might benefit from adding progesterone into the equation. However, I have heard wildly different opinions on whether it has any impact at all, and criticism of generally available creams on amazon for not being the same as human progesterone, since they are often derived from plants.
What do you girls think? Are they junk, or are there some out there worth trying?
I would take bio-identical progesterone (P4) prescribed by a doctor. The common recommendation is to press the pill (normally taken orally) up into the rectum, since taking it orally causes the liver to filter most of it. Bypassing the liver by putting it up the rectum allows it to absorb readily in the lower intestines.
See:
https://transfemscience.org/articles/transfem-intro/#rectal-progesterone
A common recommendation is to start progesterone a year or two into HRT once the breasts have reached Tanner stage III, as taking it too early supposedly can negatively impact breast development (take this with a grain of salt, may or may not be true; there is also no empirical evidence progesterone helps breast development, it’s all anecdotal reports).