Somewhere during the Early Access Larian introduced the loaded / Karmic dice, to even out extreme effects of dice rolls. In EA this was enabled at default, and I assume the same will be true for the final release. It feels like it is a less pure D&D feature, since D&D gameplay is based on die rolls.
What do you think? Play with or without the Karmic Dice option enabled? And why?
I play with it off, because I prefer to not have my rolls messed with in either direction. I don’t personally want to play with it giving me an artificial bonus and then likely dumping on me the next time I roll.
As someone else stated, if you don’t know what you’re doing keep it on for the sake of gameplay. Otherwise turn it off if you don’t want it