Hi, I was wondering, is it useful to use multiple adblockers in a row?

I don’t mean 4 or five 5 browser extensions more like a chain of adblockers, one on every passing network point.

Adblock DNS -> Pi-Hole -> Linux System with hBlock -> Browser with uBlock Origin

I have only a 10 Mbit Internet connection, so I fear that this would slowdown pageloads to much. On the other hand there are filterlists that uBlock can use where as Pi-Hole can’t.

So what combination does make sense (is efficient in every aspect) and what do you use?