(AP) — The head of the U.N. AIDS agency said Monday the number of new HIV infections could jump more than six times by 2029 if American support of the biggest AIDS program is dropped, warning that millions of people could die and more resistant strains of the disease could emerge.

In an interview with The Associated Press, UNAIDS Executive Director Winnie Byanyima said HIV infections have been falling in recent years, with just 1.3 million new cases recorded in 2023, a 60% decline since the virus peaked in 1995.

But since President Donald Trump’s announcement the U.S. would freeze all foreign assistance for 90 days, Byanyima said officials estimate that by 2029, there could be 8.7 million people newly infected with HIV, a tenfold jump in AIDS-related deaths — to 6.3 million — and an additional 3.4 million children made orphans.